Hormonal Optimization

    Hunter vs. Farmer: Why Keto (or Veganism) Might Be Making You Sick

    12 February 2026 · Elwin Robinson

    The Executive Summary

    • 1The TCF7L2 gene determines whether your body is designed to run on fats (Hunter) or carbohydrates (Farmer) — following the wrong diet causes inflammation and weight gain.
    • 2Hunters thrive on Keto/Paleo and crash on high-carb diets; Farmers thrive on Mediterranean/Plant-Based and often see thyroid dysfunction on Keto.
    • 3A simple two-day breakfast test can reveal your genetic diet type before any lab work.

    The diet wars are endless. "Keto is king!" says one expert. "Go plant-based!" says another. They are both right — and they are both wrong. They are arguing from their own biology, assuming it applies to you. The truth is written in your genes, specifically the TCF7L2 gene. This variation determines whether your body is designed to run on fats (Hunter) or carbohydrates (Farmer).

    The Hunter type evolved in cold climates with long winters and scarcity of vegetation. They have a strong insulin response to carbohydrates — a bowl of oatmeal spikes blood sugar and crashes it, leaving them tired and hungry. Hunters thrive on Keto or Paleo diets, needing protein and healthy fats for stability. If a Hunter goes vegan or high-carb, they will likely gain weight and struggle with brain fog.

    The Farmer type evolved in agricultural societies, tropical climates, and environments with abundant grains and tubers. They have high insulin sensitivity — they can eat rice or fruit and maintain stable blood sugar, converting glucose into energy efficiently. Farmers thrive on Mediterranean or plant-based diets, needing complex carbs to fuel the brain. When a Farmer tries Keto, their thyroid often crashes. They feel 'wired but tired,' lose hair, and hit a weight loss plateau because they are starving their body of its primary fuel.

    Most people fall somewhere in the middle — the 'Mixed' type. But if you have been strictly following a diet that makes you feel terrible, you are likely eating for the wrong genetic archetype. The beauty of this framework is that it replaces dogma with data.

    You can test this today without a lab using the Breakfast Test. Day 1 (Farmer test): eat oatmeal with fruit and observe how you feel two hours later — energetic or crashing? Day 2 (Hunter test): eat eggs and avocado with no toast and observe — satiated or 'empty'? Your body will tell you the answer. Your genetics just confirm why.

    The Genetic Mechanism

    TCF7L2PPARGADRB2FABP2IRS1

    TCF7L2 (Transcription Factor 7-Like 2) is the single most significant gene for type 2 diabetes risk and insulin signaling. The rs7903146 variant directly affects how your pancreatic beta cells respond to glucose. The T allele (Hunter phenotype) reduces insulin secretion efficiency, meaning carbohydrate-heavy meals overwhelm the system. The C allele (Farmer phenotype) maintains robust insulin response, enabling efficient glucose metabolism. PPARG modulates fat cell differentiation and insulin sensitivity — Pro12Ala carriers show enhanced insulin sensitivity on higher-carb diets. FABP2 Ala54Thr affects intestinal fat absorption, creating further divergence in how Hunters and Farmers process dietary fats. IRS1 variants compound these effects by altering downstream insulin receptor signaling.

    Protocol & Action

    1. 1

      Test TCF7L2 rs7903146 status through a comprehensive genetic panel — this is the primary determinant of your Hunter/Farmer classification.

    2. 2

      For Hunters (T/T or C/T): adopt a moderate-to-high fat, low-glycemic diet. Target 40-50% calories from fat, 30% protein, 20-30% low-GI carbohydrates.

    3. 3

      For Farmers (C/C): adopt a Mediterranean-style diet. Target 50-55% complex carbohydrates, 25-30% fat, 20% protein. Prioritize whole grains, legumes, and fruits.

    4. 4

      For Mixed types: use a cyclical approach — alternate higher-carb and higher-fat days based on activity level and monitor energy, mood, and body composition.

    5. 5

      Run the two-day Breakfast Test as an immediate self-assessment before genetic results are available.

    6. 6

      Validate with fasting insulin, HbA1c, and a continuous glucose monitor (CGM) for 14 days to confirm your genetic classification matches your metabolic reality.

    Stop Eating Against Your Biology

    Keto works miracles for 'Hunters' but can destroy the thyroid of 'Farmers.' Your TCF7L2 gene holds the answer. Stop following trends and start following your own source code.

    The Advanced Health Genetics All-Access Package includes a full 'Dietary Blueprint' report, telling you exactly how your body processes Fats vs. Carbs.

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