Hormonal Optimization

    Why 'Eat Less, Move More' Failed You: The 5 Hormonal Archetypes

    4 February 2026 · Elwin Robinson

    The Executive Summary

    • 1Calories matter, but your hormones determine whether those calories are burned, used for energy, or locked away in fat storage.
    • 2There are 5 Hormonal Archetypes — Leptin Resistance, Insulin Resistance, Cortisol Dominance, Estrogen Dominance, and Low Metabolism — each requiring a completely different protocol.
    • 3Most people are a combination of two archetypes; identifying your specific pattern is the key to breaking through weight loss plateaus.

    The conventional approach to health expects very little of your body. It tells you to 'just eat less and move more.' But if it were that simple, obesity wouldn't be an epidemic. Here is the truth: the law of thermodynamics holds true (calories matter), but your hormones determine how those calories are used. They decide whether a calorie is burned for heat, used for energy, or locked away in fat storage.

    Archetype 1: Leptin Resistance — The 'Hungry Brain.' You are never full. You can eat a large meal and be hunting for snacks 20 minutes later. Your brain has become deaf to the signal from your fat cells. It thinks you are starving, so it lowers your metabolism and ramps up your hunger. You cannot diet this away. You must fix the signaling through sleep and circadian rhythm.

    Archetype 2: Insulin Resistance — The 'Constant Snacker.' You get 'hangry.' You crash in the afternoon. You carry weight primarily around your belly. Your cells are refusing to accept energy from your blood. Your body responds by pumping out more insulin — the 'Fat Storage Hormone.' High insulin makes it biologically impossible to burn fat. You must lower the insulin load, not just the calorie load.

    Archetype 3: Cortisol Dominance — The 'Wired but Tired.' You wake up at 3 AM. You feel anxious but exhausted. You have stubborn belly fat that won't budge even with exercise. Chronic stress has convinced your body it is in danger. It is breaking down muscle and storing fat to prepare for a 'fight.' Intense exercise makes this worse. You need restorative movement and nervous system regulation.

    Archetype 4: Estrogen Dominance — The 'Shape Shifter.' For women, weight on the hips and thighs. For men, weight on the chest. An imbalance between estrogen and progesterone (or testosterone) is the cause. We live in an estrogenic world — plastics, pesticides — that disrupts this delicate balance. Liver detoxification support is crucial here to clear excess hormones.

    Archetype 5: Low Metabolism — The 'Cold and Tired.' You are cold all the time. Your hair is thinning. You eat very little but still gain weight. Your thyroid has dialed down the thermostat. Your mitochondria are running at 50% capacity. Eating more of the right nutrients is often required to signal safety to the thyroid. Most people are a combination of two archetypes. For example, Cortisol Dominance often leads to Insulin Resistance. The key to transformation isn't another generic diet — it's identifying your specific archetype and applying the specific protocol that unlocks it.

    The Genetic Mechanism

    LEPLEPRTCF7L2HSD11B1CYP19A1DIO2

    Each archetype has a genetic underpinning. LEP and LEPR variants determine leptin production and receptor sensitivity (Archetype 1). TCF7L2 is the strongest genetic predictor of insulin resistance and determines how your pancreatic beta cells respond to glucose (Archetype 2). HSD11B1 converts inactive cortisone to active cortisol in tissues — upregulated variants create high tissue cortisol even when blood levels appear normal (Archetype 3). CYP19A1 (aromatase) controls the conversion of testosterone to estrogen — variants that increase aromatase activity drive estrogen dominance (Archetype 4). DIO2 controls T4-to-T3 thyroid hormone conversion — Thr92Ala variants reduce conversion efficiency, creating functional hypothyroidism that standard thyroid panels miss (Archetype 5). Genotyping all six genes provides the complete archetype map.

    Protocol & Action

    1. 1

      Complete a comprehensive hormonal panel: fasting insulin, leptin, cortisol awakening response (CAR), full thyroid panel (including free T3 and reverse T3), estradiol, progesterone, and testosterone.

    2. 2

      Genotype LEP/LEPR, TCF7L2, HSD11B1, CYP19A1, and DIO2 to identify your genetic archetype predisposition.

    3. 3

      For Leptin Resistance: prioritize sleep (8 hours minimum), implement circadian light hygiene, and eliminate snacking to create metabolic silence.

    4. 4

      For Insulin Resistance: adopt a lower-glycemic eating pattern, implement 3 structured meals with no snacking, and consider berberine (500mg twice daily) or inositol supplementation.

    5. 5

      For Cortisol Dominance: replace high-intensity exercise with restorative movement (yoga, walking, swimming). Implement a 20-minute daily nervous system reset (breathwork or meditation).

    6. 6

      For Estrogen Dominance: support liver Phase II detoxification with DIM (200mg daily) and calcium-d-glucarate (500mg daily). Reduce xenoestrogen exposure (plastics, conventional produce).

    7. 7

      For Low Metabolism: ensure adequate caloric intake (undereating suppresses thyroid). Supplement with selenium (200mcg), zinc (30mg), and iodine if DIO2-compromised. Consider T3 supplementation under medical supervision.

    8. 8

      Retest hormonal panel at 90 days to confirm archetype-specific protocol is shifting markers in the right direction.

    Which Archetype Are You?

    Most people are a combination of two (e.g., Cortisol Dominance driving Insulin Resistance). To get results, you must address them in the right order.

    Identify your primary and secondary archetypes in less than 2 minutes and get a customized starting protocol.

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