Anti-Aging Protocols

The Rejuvenation Blueprint: 7 Root Causes of Aging & Disease

10 February 2026 · Elwin Robinson

The Executive Summary

1All chronic disease and aging trace back to 7 root causes — genetics, nutritional deficiencies, toxicity, chronic infections, hormonal imbalances, lifestyle stressors, and emotional blocks.
2You are only as strong as your weakest link — fixing the wrong root cause yields zero results no matter how much effort you invest.
3The Rejuvenation Blueprint provides a systematic framework for identifying and addressing your specific weakest link first.

In traditional medicine, we treat symptoms. If you have high blood pressure, you get a pill. If you have pain, you get a painkiller. But Rejuvenation — true anti-aging — requires asking a different question: Why is the body breaking down? Through my work with thousands of clients, I have mapped the 7 Root Causes of all chronic disease and aging. You are only as strong as your weakest link.

Root Cause #1: Genetic Factors. Your DNA loads the gun; your lifestyle pulls the trigger. Knowing your genetic weaknesses — such as poor methylation via MTHFR variants — allows you to 'patch' them before they break. Root Cause #2: Nutritional Deficiencies. You can eat 'healthy' and still be starving. If you have genetic absorption issues (like the VDR gene for Vitamin D), you might need 5x the normal dose just to maintain baseline health.

Root Cause #3: Toxicity. We live in a toxic soup. Heavy metals, plastics, and mould accumulate in the body, creating oxidative stress that rusts your cells from the inside out. Root Cause #4: Chronic Infections. Viruses (like Epstein-Barr), parasites, and bacterial overgrowth (SIBO) act like a constant energy drain on your battery, accelerating aging.

Root Cause #5: Hormonal Imbalances. As we age, our 'repair hormones' (Growth Hormone, DHEA) drop, and our 'decay hormones' (Cortisol, Insulin) rise. Rejuvenation requires flipping this ratio. Root Cause #6: Lifestyle Stressors. Sleep, light environment, and circadian rhythm. If you are out of sync with the sun, your body cannot repair itself at night.

Root Cause #7: Emotional & Energetic Blocks. Trauma and chronic stress keep the nervous system in 'Fight or Flight,' preventing the 'Rest and Repair' state needed for longevity. The vagus nerve — the body's primary parasympathetic highway — becomes chronically suppressed, shutting down digestion, immune surveillance, and cellular repair simultaneously.

You do not need to fix all 7 at once. You only need to find Your Weakest Link. If you have heavy metal toxicity (Root Cause #3), no amount of kale (Root Cause #2) will fix it. If you have a hidden infection (Root Cause #4), no amount of meditation (Root Cause #7) will cure it. The framework is about precision — identifying the single bottleneck that, once resolved, unlocks cascading improvements across every other system.

The Genetic Mechanism

MTHFRVDRSOD2HLA-DRCOMTCYP1A2

Each of the 7 root causes has a genetic dimension. MTHFR variants compromise methylation (Root Cause #1), reducing your capacity for DNA repair and detoxification simultaneously. VDR variants affect Vitamin D receptor sensitivity (Root Cause #2), meaning standard supplementation doses may be entirely inadequate. SOD2 variants reduce mitochondrial antioxidant defense (Root Cause #3), making you more vulnerable to toxic accumulation. HLA-DR variants determine immune response patterns (Root Cause #4), predisposing certain genotypes to chronic infections that others clear easily. COMT affects stress hormone clearance (Root Causes #5 and #7), and CYP1A2 determines Phase I detoxification speed (Root Cause #3). The Rejuvenation Blueprint uses your complete genetic profile to identify which root cause is your primary bottleneck.

Protocol & Action

1
Complete a comprehensive genetic panel covering all 7 root cause domains: methylation, nutrient absorption, detoxification, immune response, hormonal metabolism, circadian regulation, and stress response.
2
Run a baseline biomarker panel: homocysteine, hs-CRP, vitamin D, heavy metals (blood and urine), comprehensive thyroid, cortisol awakening response, and organic acids test.
3
Score each root cause domain 1-10 based on the intersection of genetic risk and current biomarker status.
4
Identify the lowest-scoring domain — this is your Weakest Link. Design a 90-day targeted protocol addressing this domain first.
5
After 90 days, retest biomarkers for the targeted domain. Once improved, reassess all 7 domains and shift focus to the next weakest link.
6
Implement foundational support across all domains simultaneously: sleep optimization (8 hours), circadian light hygiene, anti-inflammatory nutrition, and daily stress management practice.
7
Consider biological age testing (epigenetic clocks like TruAge or GrimAge) at baseline and 12 months to quantify the rejuvenation trajectory.