From Chronic Brain Fog to Laser Focus
Debilitating brain fog, memory loss, and inability to concentrate for more than 20 minutes.
Sustained focus for 4+ hours, memory restored, and cognitive performance back to peak levels.
The Challenge
A 38-year-old tech founder presented with progressive brain fog that had worsened over 18 months. He described it as 'thinking through treacle.' Short-term memory was severely impaired — he was forgetting conversations from the same day and struggling to follow complex technical discussions.
MRI scans were clear. Standard blood work showed nothing abnormal. He had tried nootropics (modafinil, racetams), lion's mane mushroom, and a carnivore diet. Nothing produced lasting improvement. He was beginning to fear early-onset dementia.
The Genetic Discovery
HLA-DR Susceptible Genotype + GSTM1 Null Deletion
Genetic testing revealed an HLA-DR variant placing him in the 25% of the population susceptible to biotoxin illness (CIRS). Combined with a GSTM1 null deletion — meaning he was missing an entire glutathione gene — his body could not tag or clear mycotoxins. A home environmental inspection confirmed significant hidden mould in his home office where he spent 10+ hours daily.
The Protocol
- 1
Immediate relocation of workspace away from the contaminated home office.
- 2
Professional mould remediation of the property.
- 3
Binder protocol: Cholestyramine (4g twice daily) to bind and escort mycotoxins from the body.
- 4
Glutathione support: NAC (1,200mg), Glycine (3g), and Liposomal Glutathione (500mg) daily to compensate for the GSTM1 deletion.
- 5
Anti-inflammatory protocol: SPM Active (specialised pro-resolving mediators) and high-dose omega-3 (4g EPA/DHA) to reduce neuroinflammation.
- 6
VIP nasal spray introduced at week 8 to restore the final stage of the Shoemaker CIRS protocol.
The Result
MoCA cognitive score improved from 22/30 to 29/30. C4a inflammatory marker dropped from 12,000 to 2,800 ng/mL. TGF-beta normalised. Urinary mycotoxin levels cleared by month 4.
The client described week 3 as 'the lights coming back on.' By month 2, he was back to leading full-day strategy sessions. He called it 'the single most important health discovery of my life.'
"I thought I was losing my mind. Turns out I was losing my ability to detoxify. One gene test changed the trajectory of my life."