HLA-DR Gene
A family of genes that helps the immune system recognize and eliminate biotoxins. Specific variants prevent the body from 'tagging' mould toxins for removal.
Deep Dive
Approximately 25% of the population carries an HLA-DR variant that makes them susceptible to Chronic Inflammatory Response Syndrome (CIRS) from mould exposure. The HLA-DR gene encodes a protein on the surface of immune cells that presents foreign substances — including biotoxins — to the immune system for identification and clearance.
While 75% of people can live in a damp house and feel fine, individuals with susceptible HLA-DR variants cannot properly 'tag' mycotoxins for removal. The toxins accumulate in fat tissue and the nervous system, causing a cascade of symptoms: brain fog, static shocks, chronic fatigue, light sensitivity, joint pain, and cognitive decline.
Standard detox protocols are often insufficient for these individuals because the immune system never initiates the clearance process. Treatment typically requires binding agents (cholestyramine or activated charcoal), removal from the mould source, and a systematic approach to reducing the total inflammatory burden. Genetic testing for HLA-DR susceptibility is a critical first step in any unexplained chronic illness workup.