COMT Gene
The gene that codes for the Catechol-O-Methyltransferase enzyme, responsible for breaking down stress neurotransmitters like dopamine, epinephrine, and norepinephrine.
Deep Dive
Your COMT status determines how you handle stress. The COMT gene produces an enzyme that metabolises catecholamines — the neurotransmitters responsible for your fight-or-flight response. A single SNP (Val158Met) dictates the speed of this enzyme, splitting the population into two broad phenotypes.
Fast COMT (Warrior): Clears stress chemicals quickly. These individuals are resilient under pressure and perform well in high-stakes environments. However, in calm or routine settings, they can feel unmotivated, bored, or seek stimulation through risk-taking behaviour. They often need deadlines and external pressure to perform at their best.
Slow COMT (Worrier): Clears stress chemicals slowly, allowing dopamine to linger. These individuals are highly focused, detail-oriented, and intellectually sharp. However, they are prone to anxiety, overthinking, and burnout under sustained pressure. They perform best with buffer time, structured routines, and calm working environments. Knowing your type is critical for designing your lifestyle, supplementation, and productivity systems around your neurochemistry rather than against it.